Design of Catalase Monolithic Tablets for Intestinal Targeted Delivery

Several studies confirmed a correlation between elevated hydrogen peroxide (H2O2) levels in patients with intestinal bowel diseases (IBD) and the negative effects caused by its presence. The objective of this study was to explore potential use catalase (CAT) diminish level H2O2 deleterious action on mucosa. Oral dosage forms CAT bioactive agent targeted intestines were designed tested various simulated gastric media. Monolithic tablets (30% loading) prepared using commercial CarboxyMethylCellulose (CMC) or synthesized CarboxyMethylStarch (CMS) TriMethylAmineCarboxyMethylStarch (TMACMS) as matrix-forming excipients. For starch derivatives, presence ionic groups (carboxymethyl trimethylamine) validated spectral analysis. In vitro have shown that formulated TMACMS 30% resisted acidity fluid gradually released enzyme into fluid. investigation release mechanism revealed role anionic cationic polymeric excipients their involvement modulation dissolution profile. proposed drug delivery system can be considered an efficient solution target intestine contribute reduction associated inflammation.